It is important for you to be well prepared for the interview. You should gather a lot of information about the company in advance and think up suitable questions. For example, questions like these:

Question 1: Will the position be newly created or refilled?
With this typical question in the interview you signal interest in the advertised position and the strategic orientation of the company. You can also use it to obtain information about how your future position within the company is to be classified: Is it a regular replacement? Or is the position being created from scratch? This may indicate that the subject area in which you will be working is fairly new to the company.